Benefits of Shiitake Mushrooms for Dogs


Dogs are cherished members of the family, and an increasing number of pet owners are turning to holistic remedies to support their companions’ health. One notable superfood gaining recognition is the shiitake mushroom. Long valued in traditional medicine, shiitake mushrooms are now being acknowledged for their potential to enhance immune function, promote cardiovascular health, reduce inflammation, and more. In this article, we will explore how this unassuming mushroom could play a pivotal role in your dog’s overall wellness.

What Are Shiitake Mushrooms?

Shiitake mushrooms (Lentinula edodes) are edible fungi native to East Asia, long prized for both their rich flavor and medicinal value. These brown, umbrella-shaped mushrooms grow on decaying hardwood trees and have been cultivated for over 2,000 years in countries like Japan and China. In fact, shiitakes have a storied history in traditional Eastern medicine as a tonic for longevity and health.

From a nutritional standpoint, shiitakes are packed with protein (they contain many of the same amino acids as meat) and are low in fat and calories. They also provide dietary fiber, vitamins, and minerals such as B vitamins, vitamin D (especially when sun-dried), selenium, copper, zinc, and potassium. This nutrient density makes them valuable as a food source. But what really sets shiitake apart are its bioactive compounds:

  • Beta-Glucans (Lentinan): A special polysaccharide unique to shiitakes, lentinan is a beta-1,3/1,6-glucan known for its immune-modulating and anti-tumor properties. It was discovered in 1970 and has since been studied for boosting immune cell activity and fighting cancerous cells.

  • Eritadenine: An amino acid derivative found in shiitake that has a potent cholesterol-lowering effect. Eritadenine helps suppress cholesterol synthesis in the liver, leading to reduced blood cholesterol levels. This compound contributes to shiitake’s heart-health benefits (more on that later).

  • Antioxidants and Other Phytonutrients: Shiitakes contain various antioxidants such as ergothioneine (sometimes dubbed a potential “longevity vitamin”) and phenolic compounds, which help protect cells from oxidative stress. They also harbor antimicrobial agents and anti-inflammatory compounds. In fact, laboratory studies show shiitake extracts have antibacterial, antiviral, antifungal, anticancer, and immunomodulatory activities.

Quick Facts: Shiitake mushrooms have been used in traditional Asian medicine for centuries as a health elixir. Modern science has identified compounds like lentinan and eritadenine in shiitake that can boost immunity, fight tumors, and lower cholesterol. 

Core Health Benefits of Shiitake for Dogs

Shiitake mushrooms offer a range of health benefits for dogs, thanks to their unique mix of nutrients and bioactive compounds. Below are some of the core benefits and how they can support your dog’s well-being:

  1. Immune System Support: Perhaps the most celebrated benefit of shiitake for dogs is its immune-boosting power. Shiitakes are rich in beta-glucans like lentinan that stimulate the immune system. These polysaccharides can activate your dog’s natural killer cells, T-cells, and macrophages – the warriors of the immune system. By “waking up” these cells, shiitake helps the body identify and fight off infections, from viruses to bacteria. In one study on healthy adults, eating just 2 dried shiitake mushrooms daily for a month significantly increased immune cell levels and reduced inflammation. Pet owners and holistic vets report similar immune perks in dogs. For dogs with underperforming immunity or those recovering from illness, shiitake can act as a natural immune booster to keep them protected.

  2. Antioxidant & Anti-Inflammatory Effects: Chronic inflammation and oxidative stress are at the root of many canine health problems – from arthritis to “inflamm-aging” in senior dogs. Shiitake mushrooms are packed with antioxidants (like selenium and ergothioneine) that neutralize harmful free radicals, protecting your dog’s cells from damage. This antioxidant action can slow down cellular aging and reduce inflammation in tissues. A recent canine study found that shiitake supplementation boosted dogs’ antioxidant levels significantly – including increased activity of superoxide dismutase (an important antioxidant enzyme) and higher expression of anti-inflammatory genes (sirtuin-1). By quelling oxidative stress, shiitakes may help manage or prevent inflammatory conditions like arthritis, allergies, and even cognitive decline in aging dogs.

  3. Cancer-Fighting Potential: Many dog owners turn to medicinal mushrooms for dogs when facing cancer, and shiitake is a standout in this regard. The beta-glucan lentinan has documented anti-tumor effects: it doesn’t kill cancer cells directly but supercharges the immune system’s ability to attack tumors. Research in humans has shown lentinan can slow tumor growth and improve survival when used alongside chemotherapy. For example, cancer patients receiving lentinan had significantly longer survival times than those on traditional cancer miedication. While direct studies in dogs are limited, veterinarians have seen promising results using shiitake extracts as an adjunct therapy for canine cancers. Lentinan may stimulate dogs’ natural killer cells to target cancer cells and even induce cancer cell apoptosis (programmed death) according to lab studies. Importantly, shiitake is not a standalone cure, but it can support a dog’s fight against cancer by enhancing immunity and possibly making tumors more responsive to treatment.  

  4. Cardiovascular Health (Heart and Circulation): What’s good for the heart in humans often applies to dogs as well. Shiitake mushrooms have several heart-healthy attributes:

    • They are naturally low in sodium and contain no unhealthy fats, making them a benign treat for the heart.

    • Shiitakes provide linoleic acid, an omega-6 fatty acid that helps maintain heart health and normal cholesterol levels.

    • Most notably, shiitake’s eritadenine and beta-glucans work to lower cholesterol. Eritadenine inhibits the enzyme involved in producing cholesterol, while beta-glucans help reduce cholesterol absorption in the gut. Shiitakes even contain sterols that further block cholesterol uptake. In animal studies, diets supplemented with shiitake led to marked drops in cholesterol – one trial in rats showed a 25% reduction in total cholesterol after just one week on shiitake mushrooms.

    For dogs, high cholesterol is not as common as in humans, but maintaining healthy blood lipids is beneficial, especially in overweight or senior dogs. A 2024 study with healthy Beagles showed that adding shiitake mushroom powder to their diet significantly lowered their blood cholesterol levels over 4 weeks. Those dogs also had improvements in blood circulation markers. Additionally, shiitake’s rich supply of copper supports blood vessel strength and healthy blood cell formation. All these factors mean shiitake could contribute to better cardiovascular health in your dog – potentially helping to keep their arteries clear and blood pressure in check (thanks in part to shiitake’s potassium content, which can aid blood pressure regulation).

  5. Digestive Health and Gut Support: A happy gut is key to a healthy dog. Shiitake mushrooms can act as a digestive aid in a few ways. They are a good source of dietary fiber, including soluble fiber that acts as a prebiotic. Prebiotics fuel the growth of beneficial gut bacteria. By feeding the “good bugs” in the intestines, shiitake may improve the balance of your dog’s microbiome, leading to better digestion and nutrient absorption. PetMD notes that mushrooms like shiitake provide fibers which help regulate bowel movements and support healthy gut flora. Dog owners have reported that adding a bit of shiitake (usually cooked or in powder form) helped firm up loose stools and reduced gassiness in their pets. Shiitakes also contain enzymes (up to 30 different enzymes, such as amylase for breaking down starch) that assist in digestion of food. And because they have anti-inflammatory effects, shiitakes might soothe the gut lining – potentially benefiting dogs with inflammatory bowel issues. Overall, incorporating shiitake could lead to more regular, comfortable digestion for your canine companion.

  6. Liver Support and Detoxification: The liver is your dog’s natural detoxifier, and shiitake mushrooms may give it a helping hand. Thanks to their antioxidants and anti-inflammatory compounds, shiitakes can protect liver cells from damage. In traditional Chinese medicine, shiitake was often used to support liver health. Modern research suggests there’s merit to this: shiitake components appear to improve fat metabolism in the liver and reduce liver inflammation. In animal studies, shiitake supplementation helped ameliorate hepatic (liver) function and prevented fat accumulation in the liver. No adverse effects on liver enzymes were seen in dogs fed high doses of shiitake, indicating it’s well tolerated by the liver. For dogs with liver strain or those on medications processed by the liver, adding shiitake (with veterinary guidance) could be a gentle way to support this vital organ’s function. Its nutrients and antioxidants assist the liver in cleansing the body of toxins.

  7. Weight Management: If your dog needs to shed a few pounds, shiitake mushrooms might become your new best friend (after your dog, of course!). Shiitakes are very low in calories but high in fiber and umami flavor, making them an excellent low-calorie, filling addition to your dog’s diet. The soluble fibers (like beta-glucan) in shiitake can increase the feeling of satiety – helping your dog feel “full” on fewer calories. One study found that laboratory animals on a high-shiitake diet had 35% less weight gain compared to those on lower doses, with significantly lower body fat accumulation. The same principles can apply to dogs: replacing some high-calorie treats with a tasty shiitake supplement or cooked mushroom pieces may aid in weight control. Shiitake’s phytonutrients also support metabolism and fat processing. Of course, weight loss in dogs still requires proper portion control and exercise, but shiitake can be a helpful component of a weight management plan as a healthy treat or food topper.

  8. Skin and Coat Health: A shiny coat and healthy skin are signs of a thriving dog. Shiitake mushrooms contain nutrients that promote skin and fur health, notably selenium and zinc. Selenium is a trace mineral that plays a role in skin integrity, coat quality, and thyroid function. Adequate selenium (along with vitamin E) can improve coat glossiness and help with skin issues. Shiitakes are a good natural source of selenium, and also provide zinc, which aids in skin repair and wound healing. If your dog suffers from dry skin or a brittle coat, the added micronutrients from shiitake could make a visible difference over time. Additionally, the anti-inflammatory properties might ease skin itching or redness from allergies. There’s even research showing beta-glucans can benefit dogs with chronic atopic dermatitis (allergic skin disease): in one trial, dogs given beta-1,3/1,6-glucan had noticeable improvements in itchiness, redness, and overall skin condition. By enhancing immune responses and reducing inflammation, shiitake’s compounds help the skin barrier fend off irritants and heal more efficiently. The result? Potentially less scratching and a softer, healthier coat.

  9. Energy and Vitality: Another benefit noted especially in older dogs is an increase in overall vitality after adding mushrooms like shiitake. B vitamins abundant in shiitakes (niacin, B5, B6, folate) help convert food into energy and support brain function. Dog nutritionists often emphasize B-vitamins for senior dogs to combat lethargy and cognitive decline. Shiitakes also provide iron and copper which are needed for healthy red blood cells – ensuring tissues get plenty of oxygen for energy. Some holistic vets report that dogs on mushroom supplements seem to have improved stamina and alertness, possibly due to better metabolic and immune function. While this area is more anecdotal, it aligns with the idea that shiitake’s nutrients and antioxidants help maintain overall vitality, keeping your dog feeling their best.

Vet’s Tip: Every dog is different, so results can vary. Some dogs might experience multiple benefits from shiitake supplementation (for example, improved energy and better digestion), while others might have more subtle changes. Always introduce new supplements gradually and observe your dog’s response. The benefits outlined above typically manifest over several weeks of consistent use, not overnight. Patience and consistency are key when using natural remedies like shiitake mushrooms.

Scientific Research Supporting Shiitake Use in Dogs

While shiitake mushrooms have a long history of medicinal use in humans, scientific research specific to dogs is still emerging. However, the studies that have been done – along with related research on mushroom compounds – strongly suggest that shiitake can positively impact canine health. Here we highlight some key research findings:

  • Antioxidant and Metabolic Boost in Dogs (2024): A groundbreaking peer-reviewed study published in Frontiers in Veterinary Science examined shiitake mushroom supplementation in healthy dogs. Over 4 weeks, dogs received shiitake powder (at ~800 mg per kg of body weight daily). The results were striking: none of the dogs had any adverse reactions, and blood tests showed significant health improvements. The shiitake-supplemented dogs had lower total cholesterol levels by the end of the trial, indicating improved lipid metabolism. Additionally, their bodies ramped up antioxidant defenses – researchers observed a significant increase in the activity of superoxide dismutase (an enzyme that protects cells from oxidative damage) and higher expression of the SIRT1 gene which is linked to reducing inflammation and aging effects. The authors concluded that shiitake supplementation “increased antioxidative activity” in dogs and could be useful in preventing age-related diseases like obesity and metabolic syndrome. In simple terms, this study shows that shiitake can make a measurable difference in a dog’s internal health markers, potentially keeping them healthier as they age.

  • Immune Modulation and Allergy Relief: A 2024 review in the journal Microorganisms looked at beta-glucans (like lentinan from shiitake) in veterinary care. It reported that adding beta-1,3/1,6-glucans to dog diets can strengthen both innate and adaptive immunity. For example, one clinical trial cited in the review found that dogs with chronic atopic dermatitis (allergic skin disease) showed a 63% improvement in clinical signs when beta-glucans were added to their diet, compared to controls. Symptoms like itching, redness, and skin lesions diminished significantly. This provides scientific backing to the idea that shiitake’s beta-glucans help regulate an overactive immune system (as in allergies) while still bolstering overall immune defenses. Another part of the review noted that obese dogs supplemented with beta-glucans had lower blood glucose, cholesterol, and inflammatory cytokines (like TNF-alpha) than untreated obese dogs – echoing shiitake’s benefits for metabolism and inflammation. While these studies sometimes used purified beta-glucan extracts, shiitake mushrooms are one of the richest natural sources of beta-1,3/1,6-glucans. This means shiitake could be a beneficial supplement for dogs with immune-related issues – helping the body find a healthier balance.

  • Cancer Therapy Support: Direct studies on shiitake for canine cancer are still limited, but we can draw insights from related research on other medicinal mushrooms in dogs. A notable example is a University of Pennsylvania study on canine hemangiosarcoma (an aggressive blood vessel cancer). Dogs treated with a compound from the turkey tail mushroom had the longest survival times ever reported for that cancer. This illustrates the profound impact medicinal mushrooms can have on the canine immune system’s ability to fight cancer. Shiitake shares similar polysaccharide compounds (like lentinan) with turkey tail. In veterinary practice, shiitake extracts are often used alongside other mushrooms to support dogs undergoing chemotherapy or facing cancers such as lymphoma, osteosarcoma, or mast cell tumors. Human oncology research further bolsters shiitake’s reputation: multiple clinical trials in people have shown that lentinan, administered with standard cancer treatments, can improve quality of life and extend survival in cancers like gastric, colon, and liver cancer. These outcomes are attributed to shiitake’s immune-enhancing and anti-tumor effects. Translating this to our pets, holistic veterinarians sometimes incorporate shiitake-based supplements as part of an integrative cancer care plan. While more dog-specific research is needed, the existing evidence suggests shiitake can be a valuable supportive therapy – potentially slowing tumor growth and mitigating side effects of cancer treatment (some reports indicate shiitake may help dogs maintain appetite and energy during chemotherapy). Always consult your vet; ongoing studies will continue to clarify shiitake’s role in canine cancer care.

  • Holistic and Anecdotal Evidence: Beyond formal studies, many holistic veterinarians have documented the benefits of shiitake in their canine patients. Dr. Rob Silver, a holistic DVM and mushroom expert, notes that shiitake mushrooms are “in the preventative category” for dogs – packed with unique antioxidants and immune modulators. Practitioners have used shiitake supplements to help manage conditions like Cushing’s disease, where shiitake’s beta-glucans may aid adrenal balance, and to reduce allergic reactions in dogs prone to dermatitis. Shiitake is also given to support dogs undergoing chemotherapy or radiation, as it’s thought to help protect normal cells and reduce side effects like loss of appetite. These uses align with traditional claims and emerging science. While anecdotal, such clinical experiences add to the body of evidence that shiitake mushrooms contribute positively to canine health.

In summary, the scientific research – from controlled studies to clinical experience – points to shiitake mushrooms being a safe and beneficial supplement for dogs. They can enhance immune function, combat oxidative stress, and even support dogs facing serious illnesses. As research continues (with more studies underway in 2025 and beyond), we expect to learn even more about how shiitake and other medicinal mushrooms can help our furry friends live healthier, longer lives.

Safe Dosage and Forms for Dogs

If you’re considering adding shiitake mushrooms to your dog’s regimen, it’s crucial to do it in a safe and effective way. Here’s how to introduce shiitake to your dog:

  • Proper Preparation is Key: Dogs should never eat raw mushrooms, including shiitake. Raw mushrooms are not only difficult to digest due to tough cell walls (chitin), but they may also contain compounds that can be irritating or even harmful before cooking. For example, raw shiitake in humans can cause a rash known as “shiitake dermatitis” – cooking eliminates this risk. Always serve shiitake cooked (sautéed in a bit of water or broth, or simmered) or use a reputable dried/powdered form. Cooking breaks down the chitin and makes nutrients more available while removing any potentially upsetting elements. If using dried shiitake, rehydrate them in hot water and then cook. Never let your dog forage wild mushrooms, as misidentification can be fatal.

  • Forms of Shiitake for Dogs: There are a few dog-friendly forms to choose from:

    • Fresh/Food Form: You can buy fresh shiitake at the grocery store, cook them thoroughly (no seasoning or garlic/onions, please!), and offer small pieces or mix into food. Some pet parents make a mushroom broth by simmering shiitakes and adding the cooled broth to dog food.

    • Dried or Powdered Shiitake: Health stores sell dried shiitake slices or powder. These should be rehydrated and heated if not already cooked. Powder can be convenient to sprinkle on food, but make sure it’s from whole fruiting bodies (see supplement section below).

    • Shiitake Supplements: Perhaps the easiest and safest route is using a properly formulated mushroom supplement that contains shiitake (sometimes in combination with other medicinal mushrooms). These come as capsules or powder. A big advantage is that they’re prepared specifically for pets, often “double extracted” (with hot water and / or alcohol) to maximize the availability of beta-glucans and nutrients. Quality pet mushroom supplements also undergo testing for contaminants.

  • Frequency: Shiitake can be given daily as a supplement for chronic health support. If using for general wellness, some owners give it 3–4 times a week instead. Consistency yields the best results, especially for immune or antioxidant benefits, so aim for at least several times a week long-term.

  • Watching for Effects: Once you start the shiitake, observe your dog over the next few weeks. Positive changes might include improved energy, better stool consistency, or reduced itchiness. On the flip side, monitor for any signs of intolerance (detailed in the next section). If everything looks good, you’re likely in the right dosage range.

Finally, always remember that while shiitake mushrooms are nutritious, they’re not a replacement for a balanced diet. Think of them as a supplement to bolster health – your dog should still be eating a complete and balanced dog food (or balanced homemade diet) appropriate for their life stage. When used wisely, shiitake can be a wonderful addition to your dog’s health regimen.

What to Look for in a Shiitake Supplement for Dogs

Not all mushroom products are created equal. If you’ve decided to give shiitake to your dog, you want to ensure you’re using the best quality form to maximize benefits and minimize any risks. Here are some tips on selecting a shiitake supplement (or raw product) for your dog:

  • Whole Fruiting Body vs. Mycelium: This is one of the most important distinctions. The “fruiting body” of the mushroom refers to the actual mushroom you see – the cap and stem. The mycelium is the root-like fungal network that usually grows on grains in laboratory cultivation. Some mushroom supplements (especially cheaper ones) are made from mycelium on grain, rather than the actual mushroom. Why does this matter? Because the fruiting body contains far higher levels of active compounds, like beta-glucans, compared to mycelium. In fact, the mushroom cap and stem have about 500 times more beta-glucans than the mycelium! Conversely, mycelium products often contain a lot of grain starch and as little as ~6% beta-glucans, whereas pure mushroom extracts can contain up to 30–40% beta-glucans. Look for supplements that explicitly state they use “fruiting body” or “whole mushroom” and have a high beta-glucan content. 

  • Extraction Method: Raw mushrooms, even when powdered, can be hard for dogs to digest because of chitin. The best supplements undergo an extraction process (hot water or dual extract) to break down the mushroom cell walls and concentrate the beneficial compounds. For example, a “double extracted” shiitake tincture or powder means it was extracted with water (to get water-soluble polysaccharides) and with alcohol (to get terpenoids and other compounds), then combined. This yields a potent extract with enhanced bioavailability. If you’re buying dried shiitake to make at home, you effectively do a hot water extract by cooking them. For convenience, many pet owners opt for ready-made mushroom blends that include shiitake – just ensure they use a proper extraction. Check labels for terms like “standardized to X% beta-glucans” or descriptions of the extraction process.

  • Organic and Source Quality: Mushrooms are bioaccumulators, meaning they can absorb heavy metals or pollutants from their growing environment. It’s wise to choose organic shiitake products to reduce the risk of pesticides or toxins. Also, consider the source country: many high-quality medicinal mushrooms are grown in the EU, United States, Canada, or Japan under controlled conditions.  

  • No Fillers or Unnecessary Additives: Ideally, the supplement should contain just the mushroom (or mushroom extract) and perhaps a carrier like a veggie capsule. Avoid products that have a lot of fillers, artificial flavors, or chemicals – these don’t add any benefit for your dog. If you’re buying a mixed mushroom supplement, ensure shiitake is one of the listed ingredients and that each ingredient is clearly identified.

  • Reputable Brands and Certifications: Do some homework on the brand. Companies that specialize in pet supplements or medicinal mushrooms tend to have better quality control.  Reading reviews from other pet owners can also be helpful, but focus on those that mention health outcomes rather than just palatability.

  • Dosage and Label Clarity: A good product will clearly state how much to give (e.g., “1 scoop = 1 gram, give 1 scoop per 25 lbs of body weight daily”). It should also indicate the amount of active ingredients (like “200 mg beta-glucans per serving”). This transparency helps you understand what your dog is getting and compare products easily. If a label is vague or seems to hide the actual mushroom content behind proprietary blends without specifics, that’s a red flag.

Quick Checklist for Mushroom Supplements:

  • Fruiting body-based (not just mycelium)

  • Extracted (for high beta-glucan content)

  • Organic, tested for purity

  • No unwanted fillers

  • Clear dosing instructions

  • Reputable, vet-recommended brand

FAQs

Can dogs eat shiitake mushrooms?

Yes, dogs can eat shiitake mushrooms as long as they are cooked or in a proper supplement form. Shiitake mushrooms are non-toxic to dogs and in fact offer health benefits. Never feed raw or wild mushrooms, but a few pieces of cooked shiitake or a vet-approved shiitake supplement is safe and often very healthy for dogs.

What is the best way to give shiitake mushrooms to my dog?

The best way is to use a commercial mushroom supplement formulated for dogs, which ensures proper dosing and preparation. These come as powders or capsulesthat contain shiitake extract.  

How much shiitake mushroom should I give my dog?
The exact amount depends on your dog’s size and the form of shiitake.  Always follow the dosing on pet supplement labels.  

Can shiitake mushrooms help dogs with allergies or skin issues?
Shiitake’s beta-glucans can modulate the immune system, which may help dogs with allergies. Some studies have shown improvement in dogs with atopic dermatitis when given beta-glucan supplements. Pet owners also report less itching and better coat condition after using shiitake. While it’s not a guaranteed cure for all skin issues, shiitake could be a helpful addition to your dog’s allergy management plan (alongside vet-prescribed treatments).

Are there any side effects of shiitake mushrooms for dogs?
Side effects are rare. The most common would be mild digestive upset (like soft stool or gas) if a dog’s system isn’t used to the added fiber. Introducing shiitake gradually usually prevents this. A few dogs might be sensitive or allergic, leading to itching or a rash – if that happens, discontinue use. And as with any supplement, if your dog is on medications or has a serious health condition, check with your vet to avoid any potential interactions.

References

  1. Kusaba, A., & Arai, T. (2024). Shiitake mushroom powder supplementation increases antioxidative activity in dogs. Frontiers in Veterinary Science, 11:1355560. (Study demonstrating reduced cholesterol and improved antioxidant markers in dogs given shiitake).

  2. Jacoby, L. (2023). Medicinal Mushrooms for Dogs. PetMD. (Overview of various medicinal mushrooms, noting shiitake contains lentinan for immune support and nutrients like B vitamins, vitamin D, copper, etc.).

  3. Hensley, A., DVM, & Moreira, N. J. D. (2023). Shiitake Mushrooms for Dogs. DogCancer.com. (Article discussing shiitake’s beta-glucans for immune activation and cancer support in dogs, with examples of lentinan improving survival in human cancer patients).

  4. Dai, X., Zhang, J., et al. (2015). Consuming Lentinula edodes (shiitake) mushrooms daily improves human immunity: a randomized dietary intervention in healthy young adults. Journal of the American College of Nutrition, 34(6), 478–487. (Human study showing increased immune cell activity and lower inflammation after daily shiitake intake).

  5. Amaral, A. R., et al. (2024). Translating Human and Animal Model Studies to Dogs’ and Cats’ Veterinary Care: Beta-Glucans Application for Skin Disease, Osteoarthritis, and Inflammatory Bowel Disease Management. Microorganisms, 12(6), 1071. (Veterinary review highlighting beta-glucans’ immune benefits, including reduced atopic dermatitis signs in dogs and improved metabolic health in obese dogs).

  6. Coile, C., PhD. (2025). Medicinal Mushrooms for Dogs: Uses, Side Effects, and Alternatives. American Kennel Club – AKC.org. (Expert article with input from Dr. Rob Silver, noting shiitake’s uses in holistic vet medicine: stimulating white blood cells, lowering cholesterol, aiding conditions like Cushing’s, and cautioning to use fruiting body extracts).

  7. Dogs Naturally Magazine. (2022). Why Dogs Can (And Should) Eat Shiitake Mushrooms. (Article by J. Keenan compiling research on shiitake benefits: weight management in rats, antioxidants like ergothioneine, cholesterol reduction, and 10 reasons to feed shiitake. References include Beelman et al., 2020 and Ciric et al., 2011 for antimicrobial effects.)

  8. Ina, K., & Yamamoto, H. (2013). The use of lentinan for treating gastric cancer. Anticancer Agents in Medicinal Chemistry, 13(5), 681–688. (Medical review supporting lentinan’s anti-tumor effects in combination with chemotherapy, which underpins its potential benefit noted in dog cancer contexts)

  9. PetMD Editors. (2023). Nutritional Benefits of Mushrooms in a Dog’s Diet. PetMD.com. (Highlights that shiitake and other mushrooms provide fiber and essential nutrients like selenium, aiding digestive health and overall nutrition in dogs)

  10. Ciric, L., et al. (2011). In vitro assessment of shiitake mushroom (Lentinula edodes) extract for its anti-gingivitis activity. Journal of Biomedicine and Biotechnology, 2011, Article ID 507908. (Study indicating shiitake’s antimicrobial properties, showing it can reduce harmful oral bacteria without disturbing beneficial flora, reflecting shiitake’s broad antimicrobial benefits mentioned for dogs)